Operation Web Tryp was a United States Drug Enforcement Administration operation that ended on July 21, 2004 with the arrests of 10 persons. Its purpose was to investigate web sites suspected of distribution of unscheduled, unregulated tryptamines and phenethylamines of questionable legality. This trade in "grey market" drugs, which were not explicitly illegal but potentially prosecutable as drug analogs, became known as the "research chemical" trade; a euphemism for the fact that the chemicals were being sold for industrial or academic research rather than human consumption.
Five websites were involved in Operation Web Tryp:
One of these websites, pondman.nu, was allegedly taking in U.S. $20,000 per week and grossed $700,000 before being shut down. Another, racresearch.com, reportedly grossed $500,000 in 14 months.
The DEA claims that AMT sold by pondman.nu caused the April 2002 death of an 18-year-old man in upstate New York, and that 2C-T-7 and 2C-T-21 sold by americanchemicalsupply.com caused the death of a 22-year-old Louisiana man. Fourteen other non-fatal overdose incidents requiring hospitalization were also cited by the DEA.
In December 2004, using credit card information provided by the DEA, British police arrested and charged over 20 UK residents who had purchased substances through the seized web sites (Operation Ismene). A few people managed to get non custodial sentences though one person is known to have spent 3 years in UK prison. Many people ordered drugs in the UK from these websites, with the FBI passing on the details to British authorities.
In 2009 the UK has become the capital of Europe in producing and sourcing "Legal highs" according to the European Drugs Commission. These are generally cleverly modified compounds taken from natural alkaloids, however due to the nature of the government openly banning Shulgins work, no-one is releasing any form of synthesis or toxicology data in the forms of white papers- knowing it is a fast track route for prosecution.
Although these chemicals were not yet scheduled, a long shadow was cast on their legality by the 1986 Federal Analog Act. This Act and the United States v. Forbes Colorado federal district court case stipulated that the burden of proof, in regards for the intention for human consumption, was on the government if any prosecution under the Federal Analog Act was to occur. Additionally, legal ambiguities regarding the legality of certain analogs of scheduled substances had been established in the aforementioned court case (In particular, the similarities of AET and DMT were debated).
As the Analog Act requires intent that a drug analog be manufactured or sold "for human consumption" before becoming prosecutable, it's possible that the people arrested in this operation could have escaped prosecution had they been more careful in how they promoted and represented their products. Many lapses of judgement or legal knowledge on the part of the web site owners and operators contributed to their downfall, such as the marketing of "sampler packs" containing what amounted to individual dosage units of drugs and aggressive promotion of their wares specifically as psychoactive drugs in various forums, such as Usenet. Usenet readers repeatedly warned at least one site operator that they were going to run afoul of the Analog Law.